Modelli compartimentali e cinetica dei radiofarmaci. Teoria dei traccianti, modellistica compartimentale e PET quantitativa

Authors

Alberto Bestetti
University of Milan
ORCID logo https://orcid.org/0000-0002-7494-3090
DOI: https://doi.org/10.54103/milanoup.330
Keywords: Nuclear Medicine, PET, FDG, Compartmental Models, Tracer Kinetics

Synopsis

This volume introduces the theoretical and practical principles of tracer kinetics and compartmental modeling in Nuclear Medicine. After presenting the fundamental concepts of biological systems, tracers, and mathematical model analysis, the book describes the main compartmental representations and their associated differential equations. Particular emphasis is placed on positron emission tomography (PET) with 18F-FDG, including matrix formulation, Laplace transform methods, convolution theory, numerical integration, and the derivation of the Patlak graphical approach. The volume also provides practical examples and Python scripts for simulation, parameter estimation, and quantitative analysis of tracer kinetics.

 

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Author Biography

Alberto Bestetti, University of Milan

Alberto Bestetti is a physician specialized in Nuclear Medicine and Diagnostic Radiology. He is Associate Professor at the University of Milan, Department of Clinical Sciences and Community Health, and senior physician in the Nuclear Medicine Department of MultiMedica Hospital. His clinical and research activities focus on nuclear cardiology, PET imaging, and radiotracer kinetic modeling. He has authored more than 100 scientific papers in international journals and is actively involved in undergraduate and postgraduate medical education.

References

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Bookcover with pictures of a brain PET and graphs concerning radiopharmaceutical behaviour
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September 28, 2026
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Details about this monograph

ISBN-13 (15)
979-12-5510-518-3